Radhashree Maitra, Ph.D.

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• Saperstein R, Goel S, Maitra R. Noncoding RNA Profile in Reovirus Treated KRAS-Mutated Colorectal Cancer Patients. Diseases. 2023 Oct 16;11(4). doi: 10.3390/diseases11040142. PMID: 37873786; PubMed Central PMCID: PMC10594459.

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• Rahman S, Patel R, Liu J, Gaba A, Maitra R, Acuna-Villaorduna A, Kim M, Goel S. Effect of Medicaid Expansion in Reducing Racial Disparities in Early Onset Colorectal Cancer. J Racial Ethn Health Disparities. 2023 Sep 14;. doi: 10.1007/s40615-023-01756-6. [Epub ahead of print] PubMed PMID: 37707661.

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• Shaykevich A, Silverman I, Bandyopadhyaya G, Maitra R. BRG1: Promoter or Suppressor of Cancer? The Outcome of BRG1's Interaction with Specific Cellular Pathways. Int J Mol Sci. 2023 Feb 2;24(3). doi: 10.3390/ijms24032869. Review. PubMed PMID: 36769189; PubMed Central PMCID: PMC9917617.

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• Augustine T, John P, Friedman T, Jiffry J, Guzik H, Mannan R, Gupta R, Delano C, Mariadason JM, Zang X, Maitra R, Goel S. Potentiating effect of reovirus on immune checkpoint inhibition in microsatellite stable colorectal cancer. Front Oncol. 2022;12:1018767. doi: 10.3389/fonc.2022.1018767. eCollection 2022. PubMed PMID: 36387154; PubMed Central PMCID: PMC9642964

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• Sapir T, Averch Z, Lerman B, Bodzin A, Fishman Y, Maitra R. COVID-19 and the Immune Response: A Multi-Phasic Approach to the Treatment of COVID-19. Int J Mol Sci. 2022 Aug 3;23(15). doi: 10.3390/ijms23158606. Review. PubMed PMID: 35955740; PubMed Central PMCID: PMC9369212.

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• Gerber M, Goel S, Maitra R. In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&II regions preventing GTP hydrolysis. Comput Biol Med. 2022 Feb;141:105110. doi: 10.1016/j.compbiomed.2021.105110. Epub 2021 Dec 9. PubMed PMID: 34920161; PubMed Central PMCID: PMC8810633.

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• Kim SY, Maitra R, Goel S. Multimodal immune activation abilities and characteristics of reovirus. Am J Transl Res. 2021;13(12):14176-14185. eCollection 2021. PubMed PMID: 35035763; PubMed Central PMCID: PMC8748157.

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• Rahman S, Garrel S, Gerber M, Maitra R, Goel S. Therapeutic Targets of KRAS in Colorectal Cancer. Cancers (Basel). 2021 Dec 11;13(24). doi: 10.3390/cancers13246233. Review. PubMed PMID: 34944853; PubMed Central PMCID: PMC8699097.

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• Samouha A, Fogel EJ, Goel S, Maitra R. Oncolytic Virus Affects the RAS Pathway in Cancer: RNA         Sequence Analysis. J Oncol Res Ther. 2021;6(4). doi: 10.29011/2574-710X.10118. Epub 2021 Oct 27.     PubMed PMID: 34841205; PubMed Central PMCID: PMC8623657.

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• Fogel EJ, Samouha A, Goel S, Maitra R. Transcriptome Signature of Immune Cells Post Reovirus Treatment in KRAS Mutated Colorectal Cancer. Cancer Manag Res. 2021;13:6743-6754. Published 2021 Aug 27. doi:10.2147/CMAR.S324203

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• Zhang W, Acuna-Villaorduna A, Kuan K, Gupta S, Hu S, Ohaegbulam K, Albanese J, Kaumaya M, Levy R, Hwang RR, Zang X, Lin J, Liu Q, Maitra R, Goel S. B7-H3 and PD-L1 Expression Are Prognostic Biomarkers in a Multi-racial Cohort of Patients with Colorectal Cancer. Clin Colorectal Cancer. 2021 Jun;20(2):161-169. doi: 10.1016/j.clcc.2021.02.002. Epub 2021 Feb 19. PMID: 33745842

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• Sapir T, Shifteh D, Pahmer M, Goel S, Maitra R. Protein Arginine Methyltransferase 5 (PRMT5) and the ERK1/2 & PI3K Pathways: A Case for PRMT5 Inhibition and Combination Therapies in Cancer. Mol Cancer Res. 2021;19(3):388-394. doi:10.1158/1541-7786.MCR-20-0745

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• Dweck A, Maitra R. The advancement of telomere quantification methods. Mol Biol Rep. 2021;48(7):5621-5627. doi:10.1007/s11033-021-06496-6

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• Mukherjee TK, Malik P, Maitra R, Hoidal JR. Ravaging SARS-CoV-2: rudimentary diagnosis and puzzling immunological responses. Curr Med Res Opin. 2021;37(2):207-217. doi:10.1080/03007995.2020.1862532

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• Jiffry J, Thavornwatanayong T, Rao D, et al. Oncolytic Reovirus (pelareorep) Induces Autophagy in KRAS-mutated Colorectal Cancer. Clin Cancer Res. 2021;27(3):865-876. doi:10.1158/1078-0432.CCR-20-2385

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• Shifteh D, Sapir T, Pahmer M, Haimowitz A, Goel S, Maitra R. Protein Arginine Methyltransferase 5 as a Therapeutic Target for KRAS Mutated Colorectal Cancer. Cancers (Basel). 2020;12(8):2091. Published 2020 Jul 28. doi:10.3390/cancers12082091

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• Maitra R, Fogel E, Parakrama R, Goel S. Molecular Tools for Metastatic Colorectal Cancer Characterization. J Cell Immunol. 2020;2(6):359-363. doi:10.33696/immunology.2.067

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• Goel S, Ocean AJ, Parakrama R, et al. Elucidation of Pelareorep Pharmacodynamics in A Phase I Trial in Patients with KRAS-Mutated Colorectal Cancer. Mol Cancer Ther. 2020;19(5):1148-1156. doi:10.1158/1535-7163.MCT-19-1117

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• Parakrama R, Fogel E, Chandy C, Augustine T, Coffey M, Tesfa L, Goel S, Maitra R. Immune characterization of metastatic colorectal cancer patients post reovirus administration. BMC Cancer. 2020 Jun18;20(1):569.doi:10.1186/s12885-020-07038-2. PMID: 32552875; PMCID: PMC7301987.

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• Maitra R, Thavornwatanayong T, Venkatesh M, Chandy C, Vachss D, Augustine T, Guzik  H, Koba W, Liu Q, Goel S. Development and characterization of a genetic mouse model of KRAS mutated colorectal cancer. Int J Mol Sci. 2019 Nov 13;20(22). doi: 10.3390/ijms20225677. PubMed PMID: 31766149; PubMed Central PMCID: PMC6888417.

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• Rao D, Mallick AB, Augustine T, Daroqui C, Jiffry J, Merla A, Chaudhary I, Seetharam R, Sood A, Gajavelli S, Aparo S, Rajdev L, Kaubisch A, Chuy J, Negassa A, Mariadason JM, Maitra R, Goel S. Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin. Oncotarget. 2019 Sep 17;10(53):5510-5522. doi: 10.18632/oncotarget.27140.eCollection 2019 Sep 17.

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• Stavsky J, Maitra R. The Synergistic Role of Diet and Exercise in the Prevention, Pathogenesis, and Management Ulcerative Colitis: An Underlying Metabolic Mechanism. Nutrition and metabolic insights 2019. DOI: 10.1177/1178638819834526.

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• Rao D, Parakrama R, Augustine T, Liu Q, Goel S, Maitra R. Immunotherapeutic advances in gastrointestinal malignancies. NPJ Precis Oncol. 2019 Feb 5; doi: 10.1038/s41698-018-0076-8. eCollection 2019. Review. PubMed PMID: 30729176; PubMed Central PMCID: PMC6363766

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• Deutsch AL, Maitra R. miR-196a Silencing of HoxD8: A Mechanism of BRAFi Resistance. J Oncol Res Ther (2019) 4: 077. DOI: 10.29011/2574-710X.000077 open access

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• Elkaim N, Maitra R. CD1b in Review: High TCR Specificity Limits Auto-Reactivity and Radhashree Maitra* DOI: 10.26717/BJSTR.2019.12.002328. Biomedical journal of scientific & technical research. 2019 January 09; 12(5):1-7.

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• Augustine T, Maitra R, Zhang J, Nayak J, Goel S. Sensitization of colorectal cancer to irinotecan therapy by PARP inhibitor rucaparib. Invest New Drugs. 2019 Jan 5. doi: 10.1007/s10637-018-00717-9. [Epub ahead of print] PubMed PMID: 30612311.

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• Chandy C. Maitra R, Emerging Role of Transcription Factors in Epithelial Mesenchymal Transition Attributing to Metastasis of Colorectal Cancer. Cancer Science 2017: Open Access www.scientonline.org. Cancer Sci. Volume 3 • Issue 1 • 013

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• Augustine T.A, Maitra R, Goel S. Telomere length regulation through epidermal growth factor receptor signaling in cancer. Genes & Cancer, 2017 May; 8(5-6): 550–558. DOI:10.18632/ genesandcancer.140.

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• Maitra R, Augustine T.A, Dayan Y, Chandy C, Coffey M, Goel S. Toll like receptor 3 as an immunotherapeutic target for KRAS mutated colorectal cancer. Oncotarget. 2017; 8:35138-35153. DOI: 10.18632/oncotarget.16812

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• Maitra R. Toll Receptors and Emerging Virotherapy in Cancer. Editorial; Gavin J Oncol Res Ther 2016, 1: 6-9

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• Maitra R. Recent Advances in Clinical Oncology. Book chapter; Life Science Recent Innovations and Research 2016 1-16, published by International Research publication house; ISBN: 978-93-84443-53-5

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• Maitra R. Viruses and Head and Neck cancers. Editorial; Head and Neck Cancer Research 2015 December 1 (1:3) DOI: 10.21767/2572-2107.100003

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• Maitra R, Augustine T.A, Venkatesh M.K, Goel S. Reovirus Oncolysis- Role of cyclindependent kinase inhibitor 1. Cancer cell and microenvironment 2015 April 13; 2 (2): 1-5. e750 DOI. 10.14800/ccm.750;

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• Augustine T.A, Baig M, Sood A, Budagov T, Atzmon G, Mariadason J.M, Aparo S, Maitra R, Goel S. Telomere length is a novel predictive biomarker of sensitivity to anti-EGFR therapy in metastatic colorectal cancer. Br J Cancer. 2015 Jan 20;112 (2):313-318. DOI: 10.1038/bjc.2014.561

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• Maitra R, Seetharam R, Tesfa L, Augustine, T.A, Klampfer, A, Coffey M.C, Mariadason J.M, Goel S. Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan. 2014 Oncotarget. May 15;5 (9):2807-2819. PMID: 24798549

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• Maitra R, Nayak J.B, Merla A, Sood A, Augustine T.A, Baig M, Reynolds D.M, Mariadason J.M, Aparo S, Goel S. A Single Nucleotide Polymorphism in the MGMT gene is a novel prognostic biomarker in patients with metastatic colorectal cancer. British Journal of medicine and medical Research. 2015, 5 (5): 604-611, DOI:10.9734/BJMMR/2014/1284

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• Sood A, McClain D, Maitra R, Basu-Mallick A, Seetharam R, Kaubisch A, Rajdev L, Mariadason JM, Tanaka K, Goel S. PTEN Gene Expression and Mutations in the PIK3CA Geneas Predictors of Clinical Benefit to Anti-Epidermal Growth Factor Receptor Antibody Therapy in Patients with KRAS Wild-Type Metastatic Colorectal Cancer. Clinical Colorectal Cancer. 2012 Jun;11 (2):143-50. DOI: 10.1016/j.clcc.2011.12.001

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• Maitra R, Ghalib MH, Goel S, REOVIRUS: A Targeted Therapeutic- Progress and Potential.Mol CancerRes. 2012 (AACR Journal) Dec; 10 (12):1514-1525. DOI: 10.1158/1541-7786.MCR12-0157.

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• Maitra R, Follenzi A, Yaghoobian A, Montagna C, Merlin S, Cannizzo ES, Hardin JA, Cobelli N, Stanley ER, Santambrogio L. Dendritic cell-mediated in vivo bone resorption. J Immunol. 2010 Aug 1;185 (3):1485-91. 25. DOI: 10.4049/jimmunol.0903560.

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• Maitra R, Clement C.C, Scharf B, Crisi G.M, Chitta S, Paget D, Purdue P.E, Cobelli N, Santambrogio L. Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis. Mol Immunol. 2009 Dec; 47 (2-3). 175-84 DOI: 10.1016/j.molimm.2009.09.023.

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• Clement C.C, Maitra R, Sahu R, Santambrogio L. Self –peptidomic repertoire of the human pre- nodal lymph. FASEB J. 2009 23:857.

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• Maitra R, Sadofsky M.J. "A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions."Nucleic Acids Res.2009 Jun; 37 (10) :3301-3309. DOI: 10.1093/nar/gkp192.

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• Bunbury A, Potolicchio I, Maitra R, Santambrogio L. Functional analysis of monocyte MHC classII compartments FASEB J. 2009 Jan;23 (1):164-71 DOI: 10.1096/fj.08-109439.

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• Maitra R, Clement C.C, Crisi G.M, Cobelli N, Santambrogio L. Immunogenecity of modified alkane polymers is mediated through TLR1/2 activation. PLoS ONE. 2008 Jun 18; 3 (6) DOI :10.1371/journal.pone.0002438.

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• Santambrogio L, Maitra R , Xie L, Wang X, Cobelli N. J Hardin J.A . Dendritic cells responses to polyethylene particle: Potential triggers for aseptic osteolysis. Osteoarthritis and Cartilage. 01/2007; 15. DOI:10.1016/S1063-4584(07) 1771-3

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• Zak E.A, Norling B, Maitra R, Huang F, Anderson B, Pakrasi H.B. (2001) The initial stepsof biogenesis of cyanobacterial photosystems occur in plasma membranes. Proc Natl Acad Sci U S A. 98, 13443-8. PMID: 11687660

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• Inagaki N, Maitra R, Satoh K. Pakrasi H.B. (2001) Amino acid residues that are critical for in vivo catalytic activity of CtpA, the carboxyl-terminal processing protease for the D1 protein of photosystem II. J Biol Chem, 276, 30099-105. PMID: 11408480

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• Maitra R, Thakur A.R. (1993) Multiple fragment ligation on glass surface: A novel approach. Indian Journal of Biochemistry and Biophysics, 31, 97-99. PMID: 7927440

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• Maitra R, Thakur A.R. (1993) Hydroxyl radical induced DNA damage: choice of an in vitro model. International Journal of Toxicology, Occupational and Environmental Health. 56, 6-7. doi.org/10.1080/01621459.2011.646935

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• Maitra R Thakur A.R. (1992) Salinization of glass bound baked DNA permits enhanced polymerization by DNA polymerase. Current Science 62, 586-588.